Endocrine Abstracts

The link between thyrotoxicosis and coronary artery disease is complex with associations between therapy and vasculitis, as well as thyroid hormone excess and coronary artery spasm described. We present a 37-year-old female with a one-year history of Graves thyrotoxicosis treated with Propylthiouracil, who presented acutely with chest pain and a left hemiparesis. Typical electrocardiography changes and elevation of Troponin T confirmed a recent myocardial infarction, and CT sc...

We report 2 patients with Graves’ thyrotoxicosis complicated by jaundice.Case 1 - A 36 year old referred to the gastroenterologists with a 3-month history of general malaise, myalgia, jaundice, 4 stone weight loss and diarrhoea. A hepatitis and autoimmune liver screen were negative, bilirubin elevated at 200 umol/l, coagulation screen and ultrasound scan were normal and a liver biopsy showed cholestasis. Thyroid function tests (TFT’s) demonstra...

Background: Magnesium, the second most abundant intracellular cation, plays a key role in cellular and metabolic reactions including protein synthesis, neurotransmission and electrolyte balance. There are no specific signs or symptoms of hypomagnesaemia and it can coexist with other electrolyte abnormalities. According to various surveys the prevalence of low Magnesium varies between 2–10% in hospitalized patients. However, there are no clear guidelines about when to scre...

Thyroid hormone resistance (THR) is associated with elevated FT4 and FT3 with inappropriately high TSH levels. T3 action is mediated by two types of thyroid hormone receptor, encoded by alpha and beta genes. We evaluated the endothelial function of a THR transgenic mouse model with a targeted mutation in the thyroid hormone beta receptor gene ex vivo.Isometric tension of aortic rings of 10 mice of each genotype (TRbPV/PV, TRbPV/+</...